Autoimmune Psychosis: Fingerprints of Aluminum-Induced Autoimmunity?

Outstanding report from James Lyon Weiler on the connection between aluminum toxicity and psychosis.

jameslyonsweiler.com

Autoimmune encephalitis is a condition in which the immune system attacks brain proteins.  It was first described by Dalmau in a patients with teratoma who exhibited high levels of autoantibodies that were reactive to neuronal tissue.  These patients also experienced severe psychotic and neurological manifestations, including anxiety, delusions, mania, short-term memory loss and seizures [1]. Immunomodulation and tumor resection reversed the symptoms.

It is well established that aluminum hydroxide can induce autoimmunity of many forms in animal models.  We recently had a paper on the issue of dose relevance to humans accepted and then not published by the journal Autoimmunological Reviews (first because it was too controversial, and then because we dared to have published a draft copy of the manuscript in the name of Open Science).  Our analysis showed that the per body weight aluminum hydroxide dosing in animal models overlapped the exposure experienced by humans when the…

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